Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human)) | BDBM50522839 (CHEMBL2095003 | DNDI1417825) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 720 | n/a | n/a | n/a | n/a | n/a |
Huazhong Agricultural University Curated by ChEMBL | Assay Description Binding affinity to N-terminal 6-His-tagged IDH1 R132C mutant (unknown origin) expressed in BL21 cells assessed as equilibrium dissociation constant ... | Bioorg Med Chem 27: 3229-3236 (2019) Article DOI: 10.1016/j.bmc.2019.05.040 BindingDB Entry DOI: 10.7270/Q2571GFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human)) | BDBM50068270 ((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.81E+3 | n/a | n/a | n/a | n/a | n/a |
Guizhou Medcial University Curated by ChEMBL | Assay Description Binding affinity to IDH1 R132C mutant (unknown origin) by surface plasmon resonance assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126825 BindingDB Entry DOI: 10.7270/Q2P55S1D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human)) | BDBM50522839 (CHEMBL2095003 | DNDI1417825) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a |
Huazhong Agricultural University Curated by ChEMBL | Assay Description Binding affinity to N-terminal 6-His-tagged IDH1 R132H mutant (unknown origin) expressed in BL21 cells assessed as equilibrium dissociation constant ... | Bioorg Med Chem 27: 3229-3236 (2019) Article DOI: 10.1016/j.bmc.2019.05.040 BindingDB Entry DOI: 10.7270/Q2571GFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human)) | BDBM50111796 (CHEMBL3605384) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a |
Baylor College of Medicine Curated by ChEMBL | Assay Description Binding affinity to recombinant human IDH1 R132H mutant expressed in Escherichia coli by isothermal titration calorimetric analysis in absence of NAD... | J Med Chem 58: 6899-908 (2015) Article DOI: 10.1021/acs.jmedchem.5b00684 BindingDB Entry DOI: 10.7270/Q2M61N2D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human)) | BDBM50111796 (CHEMBL3605384) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a |
Baylor College of Medicine Curated by ChEMBL | Assay Description Binding affinity to recombinant human IDH1 R132H mutant expressed in Escherichia coli by isothermal titration calorimetric analysis in presence of NA... | J Med Chem 58: 6899-908 (2015) Article DOI: 10.1021/acs.jmedchem.5b00684 BindingDB Entry DOI: 10.7270/Q2M61N2D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human)) | BDBM50068270 ((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.28E+4 | n/a | n/a | n/a | n/a | n/a |
Guizhou Medcial University Curated by ChEMBL | Assay Description Binding affinity to IDH1 R132H mutant (unknown origin) by surface plasmon resonance assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126825 BindingDB Entry DOI: 10.7270/Q2P55S1D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human)) | BDBM50557557 (CHEMBL504910) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 1.53E+4 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to C-terminal His6-tagged IDH1 R132H mutant (unknown origin) expressed in Escherichia coli BL21 (DE) measured after 20 mins by Red-N... | Citation and Details Article DOI: 10.1016/j.bmc.2021.116095 BindingDB Entry DOI: 10.7270/Q20Z76ZZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human)) | BDBM50378034 (CHEMBL504404 | NSC-287088 | PHYSALIN B) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 4.53E+4 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to C-terminal His6-tagged IDH1 R132H mutant (unknown origin) expressed in Escherichia coli BL21 (DE) measured after 20 mins by Red-N... | Citation and Details Article DOI: 10.1016/j.bmc.2021.116095 BindingDB Entry DOI: 10.7270/Q20Z76ZZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human)) | BDBM50111796 (CHEMBL3605384) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 4.60E+4 | n/a | n/a | n/a | n/a | n/a |
Baylor College of Medicine Curated by ChEMBL | Assay Description Binding affinity to recombinant human IDH1 R132H mutant expressed in Escherichia coli by isothermal titration calorimetric analysis in presence of NA... | J Med Chem 58: 6899-908 (2015) Article DOI: 10.1021/acs.jmedchem.5b00684 BindingDB Entry DOI: 10.7270/Q2M61N2D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human)) | BDBM50522839 (CHEMBL2095003 | DNDI1417825) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a |
Huazhong Agricultural University Curated by ChEMBL | Assay Description Binding affinity to N-terminal 6-His-tagged wild type IDH1 (unknown origin) expressed in BL21 cells assessed as equilibrium dissociation constant by ... | Bioorg Med Chem 27: 3229-3236 (2019) Article DOI: 10.1016/j.bmc.2019.05.040 BindingDB Entry DOI: 10.7270/Q2571GFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human)) | BDBM50068270 ((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a |
Guizhou Medcial University Curated by ChEMBL | Assay Description Binding affinity to IDH1 (unknown origin) by surface plasmon resonance assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126825 BindingDB Entry DOI: 10.7270/Q2P55S1D | |||||||||||
More data for this Ligand-Target Pair |